The effect of various digital parameters, such as the sampling aperture, sampling distance, and display aperture, on the modulation transfer function (MTF) of digital radiographic imaging systems was investigated by means of theoretical simulation studies. The MTFs were also determined experimentally to confirm the relationship used in the simulation studies. The results indicate that the overall MTF of a digital system cannot specify the resolution properties in the same way as can the MTFs of analog systems. The MTF of a digital system may include a “false” response due to aliasing, which could lead to an incorrect interpretation of the resolution properties. The magnitude of aliasing that will occur in a digitized signal depends on the sampling parameters chosen and on the frequency content of the radiologic object being imaged. Thus, the type of object to be detected as well as various digital parameters must be considered in the design and evaluation of digital imaging systems.