Immunisation of mice againstStrongyloides ratti

Publisher Website
Google Scholar
Abstract
Experimental infections of C57B1/6 mice withStrongyloides ratti produced marked resistance to challenge. Resistance to reinfection was induced by as few as six filariform larvae. The degree of resistance produced by soluble somatic antigens prepared from filariform larvae ofS. ratti was comparable to that seen after a primary infection. The addition of Freund's adjuvants to the antigen did not increase resistance significantly. Intraperitoneal implantation of micropore chambers containing filariform larvae failed to induce resistance to reinfection. Considerable resistance to a challenge infection withS. ratti was found after infection withS. stercoralis.