A New Strategy for the Synthesis of Polychlorinated Biphenyl Metabolites
- 1 January 1995
- journal article
- Published by American Chemical Society (ACS) in Chemical Research in Toxicology
- Vol. 8 (1) , 92-95
- https://doi.org/10.1021/tx00043a012
Abstract
A general and high-yielding synthetic route is presented by which a variety of chlorinated dihydroxybiphenyl metabolites may be synthesized. These synthetic standards will permit the investigation of novel pathways of polychlorinated biphenyl activation. The biphenyldiols were synthesized via palladium-catalyzed cross-coupling of dimethoxyphenylboronic acids with aryl bromides in the presence of a base. The formed dimethoxybiphenyls were demethylated using boron tribromide to yield the chlorinated dihydroxybiphenyls. These compounds were characterized by IR, NMR, and GC/MS.Keywords
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