N‐myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS

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Abstract
DNA from 13 (6 alveolar and 7 embryonal) childhood rhabdomyosarcomas (RMS) was examined to determine the incidence and prognostic relevance of N‐ and c‐myc genes. Southern analysis showed 5‐ to 20‐fold amplification of N‐myc gene in 4 of 6 alveolar but in none of 7 embryonal RMS (p < 0.04; Fisher's exact test). The number of children who died with multiple‐ and single‐copy N‐myc gene was 4/4 and 5/9 respectively (p > 0.05; Chi‐squared test). There was no statistically significant correlation between N‐myc amplification and age, gender, site, stage or survival time. There was no amplification or gross rearrangement of c‐myc in any of the 13 RMS.