This paper describes 6 patients with the syndrome of ophthalmoplegic polyneuritis fairly identical to that described by Fisher. The most striking symptom of the ophthalmoplegic polyneuritis is the acute ophthalmoplegia, usually total and bilateral, often with sparing of the pupillary reflexes and of the levater palpebrae. The disturbances may simulate a paralysis of gaze or a internuclear palsy. Following features may announce this illness: mild harmless infectious disease, sensory deficits, generalized hyporeflexia or areflexia, albuminocytologic dissociation. There is without a specific treatment a complete recovery within months. Often it is impossible to clarify the etiology.