BRONCHODILATING EFFECT AND SIDE-EFFECTS OF BETA-ADRENOCEPTOR STIMULANTS BY DIFFERENT MODES OF ADMINISTRATION (TABLETS, METERED AEROSOL, AND COMBINATIONS THEREOF) - STUDY WITH SALBUTAMOL IN ASTHMATICS

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Abstract
Cumulative dose-response curves in humans for routes of administration concerning 1-s forced expiratory volume, forced vital capacity, heart rate, blood pressure and tremor were constructed. Tremor apparently was the dose-limiting side-effect with both modes of adminstration. The metered aerosol in doses as large as 0.6 mg produced a greater increase in the 1-s forced expiratory volume, with fewer side-effects than could be achieved with tolerable doses of salbutamol by mouth. An oral dose of 6 mg is probably the maximal tolerable dose in most cases. Oral treatment apparently had a better effect than inhalation treatment on the forced vital capacity at the same effect on 1-s forced expiratory volume, possibly due to a better effect on small peripheral airways. The effect of combining different oral doses of salbutamol with inhaled salbutamol was studied. A very good additional effect of inhalations given orally after 4 and 6 mg was shown.