Myxofibrosarcoma: a pathologico-anatomical, microangiographic and angiographic correlative study of eight cases

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Abstract
A correlated angiographic, microangiographic and histological study of 8 myxofibrosarcomas is presented. Myxofibrosarcoma is a very recently described type of malignant soft tissue tumor characterized by a mucoid and nodular appearance, predominantly arising superficially in the extremities and trunk in elderly people. Microscopically, the lobulated and myxoid tumors in the present series showed a characteristic plexiform network for fine capillary-like vessels and occasional wide, sinusoidal, angulated vessels. On plain radiographs they were dense and well demarcated. Angiographically the tumors appeared highly vascular, with irregular tumor vessels often arranged in a patchy or nodular fashion. All revealed signs of rapid circulation. The microscopic and angiographic appearances were correlated, in 2 cases utilizing microangiography. In the presence of a superficially located tumor with high density on plain radiographs, marked vascularity, patchy or nodular opacities and signs of rapid circulation on angiograms one should suspect this diagnosis.