EXCRETION OF COPROPORPHYRIN IN HEPATIC DISEASE
- 1 January 1943
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 71 (1) , 62-67
- https://doi.org/10.1001/archinte.1943.00210010068005
Abstract
As stated in previous papers of this series,1 it is probable that porphyrin arises within the body during the process of synthesis of hemoglobin, protoporphyrin III composing the prosthetic group of hemoglobin, myoglobin and various respiratory ferments,2 and that porphyrin of isomeric series I, which arises as a useless by-product during this synthesis, as well as any porphyrin of isomeric series III that is not utilized, is excreted in the urine and feces as coproporphyrin. The total amount of coproporphyrin excreted as well as the ratio of urinary to fecal excretion depends chiefly on the rate of production of porphyrin and the efficiency of the liver, which is the more important organ of excretion of porphyrin, the kidneys normally excreting but a small fraction of the total porphyrin excreted.3 It has been demonstrated that in the event of parenchymatous hepatic damage the ratio of urinary excretion toThis publication has 5 references indexed in Scilit:
- EXCRETION OF COPROPORPHYRIN IN HEPATIC DISEASEArchives of internal medicine (1960), 1942
- EXCRETION OF COPROPORPHYRIN IN HEPATIC DISEASEArchives of internal medicine (1960), 1942
- THE METABOLISM OF BLOOD PIGMENTS IN PERNICIOUS ANEMIAJournal of Clinical Investigation, 1938
- CONCERNING THE NATURALLY OCCURRING PORPHYRINS. IV. THE URINARY PORPHYRIN IN LEAD POISONING AS CONTRASTED WITH THAT EXCRETED NORMALLY AND IN OTHER DISEASES 1Journal of Clinical Investigation, 1936
- Transformation of haemins into bile pigmentsBiochemical Journal, 1935