Alphalipoprotein cholesterol levels in relation to acute myocardial infarction and its risk factors

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Abstract
During 1975-1977, 29 males surviving acute myocardial infarction at 40-44 yr old were registered in Gothenburg, Sweden; 25 of these were studied and compared with 2 control groups. The reference group (RG, n = 76) was randomly selected from the male population from which the acute myocardial infarction (AMI) group was derived. A matched control group (MC, n = 47) consisted of men with no history of coronary heart disease, matched with patients for age, serum cholesterol and body weight index. Serum triglyceride levels were higher and .alpha.-lipoprotein cholesterol lower in the AMI group than in RG. Prior to infarction patients had a higher degree of physical activity at work and a higher tobacco consumption than RG. When AMI cases were compared with MC subjects lower .alpha.-lipoprotein cholesterol levels were found in AMI, and they had a higher tobacco consumption prior to infarction. There was a negative correlation between .alpha.-lipoprotein cholesterol levels and tobacco consumption in the RG. The differences in .alpha.-lipoprotein cholesterol levels between AMI cases and controls could not be attributed to smoking habits, but smoking may to some extent exert its effect as a risk factor through influence on .alpha.-lipoprotein cholesterol levels.