The Michael Addition of Sulfur Anions to β,β-Substituted Nα-Formyl-α, β-Dehydroamino Acid Esters
- 1 April 1988
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 18 (5) , 531-543
- https://doi.org/10.1080/00397918808060748
Abstract
The addition of lithium benzylthiolates to Nα,-formyl-α,β-dehydro-α-amino acid esters gave protected Nα-formyl-β-S-benzyl-β,β-dialkylcysteine esters. Hydrolysis and Nα-protection produced β,β-dialkyl-cysteines which can be used for peptide synthesis.Keywords
This publication has 4 references indexed in Scilit:
- Preparation of .beta.,.beta.-dialkyl analogs of cysteine suitable for peptide synthesisThe Journal of Organic Chemistry, 1986
- Design of peptide hormone and neurotransmitter analoguesTrends in Pharmacological Sciences, 1985
- Chapter 30. Recent Progress in the Rational Design of Peptide Hormones and NeurotransmittersPublished by Elsevier ,1984
- Synthesen mit α‐metallierten Isocyaniden, XVI1) β‐Substituierte α‐Formylamino‐acrylsäureäthylester aus α‐metallierten Isocyanessigestern und Carbonylverbindungen (Formylaminomethylenierung von Carbonylverbindungen)European Journal of Organic Chemistry, 1973