Nuclear receptor corepressors
Open Access
- 1 January 2003
- journal article
- Published by SAGE Publications in Nuclear Receptor Signaling
- Vol. 1 (1) , e001
- https://doi.org/10.1621/nrs.01001
Abstract
The ability of NR LBDs to transfer repression function to a heterologous DNA binding domain, and the cross-squelching of repression by untethered LBDs, has suggested that repression is mediated by interactions with putative cellular corepressor proteins. The yeast-two hybrid screen for protein interactors has proven to be the key to the isolation and characterization of corepressors. This short review will focus on N-CoR and SMRT.Keywords
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