The Effect of Cycloheximide on the Replication of Measles Virus

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Abstract
Treatment of measles virus-infected [African green monkey kidney Vero] cells with cycloheximide results in a 3-fold increase of 3H-uridine incorporation into the 12-36S mRNA species and in the inhibition of genomic 50S RNA synthesis. Consistent with these observations was the finding of a build-up of polyribosomes but an absence of nucleocapsids in the infected cells. Measles virus RNA replication, but not transcription, may be dependent on active protein synthesis.

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