Enzymatic Resolution of Medium-Ring Lactones. Synthesis of (S)-(+)-Phoracantholide I
- 1 January 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1989 (09) , 661-666
- https://doi.org/10.1055/s-1989-27351
Abstract
The horse liver and pig liver esterase hydrolysis of racemic medium ring lactones gives with excellent enantiomeric excess the S- (or R) lactones and the corresponding R- (or S) hydroxy acids. This is the first general method to obtain optically pure medium ring lactones. Application to the preparation of (S)-(+)-Phoracantholide I is reported.Keywords
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