ROLE OF MACROPHAGES IN DEFECTIVE CELL-MEDIATED-IMMUNITY IN LEPROMATOUS LEPROSY .1. FACTOR(S) FROM MACROPHAGES AFFECTING PROTEIN-SYNTHESIS AND LYMPHOCYTE-TRANSFORMATION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 48  (2) , 172-177
Abstract
Macrophages from lepromatous leprosy patients specifically show reduced protein synthesis in the presence of Mycobacterium leprae. They also produce, as a result of interaction with M. leprae, factor(s) that reduce protein synthesis in normal macrophages and block lymphocyte transformation in normal leukocyte cultures in the presence of M. leprae as the antigen. These observations implicate a defective macrophage system in lepromatous leprosy patients.