Excretion of cadmium through bile and intestinal wall in rats

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Abstract
Cikrt, M., and Tichý, M. (1974).British Journal of Industrial Medicine,31, 134-139. Excretion of cadmium through bile and intestinal wall in rats. The excretion of Cd2+ through the bile and intestinal wall after intravenous administration of CdCl2 in non-toxic doses (67, 90, and 120 μg of Cd2+ per rat) was studied in rats. The cumulative biliary excretion reached 24 hours after administration of the 67 μg dose was 0·83%, after 90 μg 1·18%, and after the 120 μg dose 5·68% of the amount given. The highest excretion rate of Cd2+ was detected between 15 and 30 minutes after administration. There was no difference in the excretion through intestinal wall between the 67 and 120 μg doses of Cd2+ per rat. The mean amount of cadmium found in the contents of the entire gastrointestinal tract and faeces was 5·5% of the administered dose. Using polyacrylamide gel disc electrophoresis it was found that Cd2+ is bound with at least two different components of the rat bile.

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