RENAL-VEIN OUTFLOW RECORDING IN RATS AND RABBITS - ALTERNATIVE METHOD OF RBF MEASUREMENT

  • 1 January 1988
    • journal article
    • research article
    • Vol. 72  (3-4) , 335-342
Abstract
A method is described for continuous measurement of total renal blood flow in anesthetized rats and rabbits. It consists of recording time intervals in which a fixed volume of renal vein outflow enters into an extracorporeal renal vein-jugular vein shunt and is pumped back to animals'' circulation. This technique yields absolute flow values of unequalled accuracy and requires virtually no calibration; however, it is not suitable for recording rapid flow transients. The RBF measured averaged 5.5 .+-. (SE) 0.1 ml/min .cntdot. g kidney weight in rats and 2.5 .+-. 1.1 ml/min .cntdot. g in rabbits; the flow was stable over at least 1.5-2 hrs. The rat kidneys tested showed usual capacity to autoregulate blood flow during graded reduction in renal perfusion pressure.

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