Corpus Callosum and Pentylenetetrazol Convulsions

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Abstract
Introduction It was shown previously that cats and white rats which had undergone removal of one cerebral hemisphere or of a frontal lobe, including the motor cortex, were more susceptible to pentylenetetrazol convulsions than unoperated animals.1-3The question remained as to which regions of the central nervous system were sensitized by these operations. An answer to this question was sought in the present investigation by testing the effects of pentylenetetrazol on Sprague-Dawley rats in which partial denervation was confined to cerebral cortical neurones. This was accomplished by sectioning the corpus callosum. Experimental Procedure Male Sprague-Dawley rats were divided randomly into 3 groups. In one group the corpus callosum was sectioned aseptically under pentobarbital (Nembutal) anesthesia, one control group was left intact, and in another a sham trepanation was performed under identical conditions with the corpus callotomy. One to 5 months after the operation, the CD50(median convulsant dose)

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