Tolytoxin and New Scytophycins from Three Species of Scytonema
- 1 November 1990
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 53 (6) , 1533-1542
- https://doi.org/10.1021/np50072a021
Abstract
Tolytoxin [1], the major cytotoxin associated with Scytonema mirabile strain BY-8-1, Scytonema burmanicum strain DO-4-1 and Scytonema ocellatum strains DD-8-1, FF-65-1, and FF-66-3, has been shown to be 6-hydroxy-7-O-methylscytophycin B. Minor amounts of three other new cytotoxic scytophycins, 6-hydroxyscytophycin B [2], 19-O-demethylscytophycin C [3], and 6-hydroxy-7-O-methylscytophycin E [4], have also been isolated from these cyanophytes. The gross structures and stereochemistry are based on nmr and cd analysis and on comparison with scytophycins A-E.Keywords
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