Genetic Factors in Human Allergic Contact Dermatitis

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Abstract
Genetic factors in the variability of developing allergic contact dermatitis were studied by comparing susceptibility of parents and their children to contact sensitization with dinitrochlorobenzene (DNCB) and paranitrosodimethylaniline (NDMA). Subjects were exposed to DNCB and NDMA by application of 0.25 ml of a 1:1000 solution in acetone to the flexor surface of the forearm. Elicitation with the same concentration was performed 20 days later. Children whose parents were sensitized became sensitized at a higher rate than did children whose parents were not sensitized, the differences reaching the 0.01 level of significance for the NDMA data. The analysis of 2, 3 and 4-member family groups by the Chi-square test for goodness of fit to the theoretical binomial distribution revealed a strong tendency toward familial aggregation, which reaches the 0.05 level of significance in the NDMA data. Genetic factors play a role in susceptibility to human allergic contact dermatitis.

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