EEG monitoring of focal lesions of the blood-brain barrier

Abstract
A modified method for the EEG detection and monitoring of small focal blood-brain barrier (BBB) lesions is presented. The method uses high dose IV penicillin (1.2 .times. 106 .mu.g/kg) to produce a spike focus at BBB lesions, penicillin encephalopathy. The EEG is recorded and the epileptic spikes are counted by an automatic computer program. The computer counting produces an objective quantitative result. The method is verified empirically on traumatic and radiative BBB lesions.