Outcome of invasive pneumococcal disease: a UK based study

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Abstract
METHODS The records of 106 children aged less than 5 years with invasive disease caused byStreptococcus pneumoniae were reviewed. RESULTS The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and seven had persisting neurological impairment. Five serotypes caused 83% of disease and 92% of the serotypes are included in the seven valent conjugate vaccines which are undergoing trials. CONCLUSIONS These data suggest that S pneumoniae infection is associated with a low case fatality rate but substantial morbidity in the UK.