Pulmonary Langerhans'-Cell Histiocytosis

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Abstract
Pulmonary Langerhans'-cell histiocytosis forms part of a spectrum of diseases characterized by monoclonal proliferation and infiltration of organs by Langerhans' cells (Table 1).1 Several organ systems may be involved in Langerhans'-cell histiocytosis, including the lungs, bone, skin, pituitary gland, liver, lymph nodes, and thyroid.2 Lung involvement may occur either in isolation or as part of a multiorgan disease (Table 1). The term “pulmonary Langerhans'-cell histiocytosis” is used to refer to disease in adults that affects the lung, either in isolation or in addition to other organ systems.Localized forms of Langerhans'-cell histiocytosis have previously been referred to as eosinophilic granuloma, . . .

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