Successful Boosting of a DNA Measles Immunization with an Oral Plant-Derived Measles Virus Vaccine
Open Access
- 1 August 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (15) , 7910-7912
- https://doi.org/10.1128/jvi.76.15.7910-7912.2002
Abstract
Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.Keywords
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