Visual evoked responses in humans with abnormal visual experience.

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Abstract
1. The visual evoked response to a grating target of varying spatial frequency was examined for normal subjects and for subjects with meridional amblyopia. This condition, reduced visual resolution for specific target orientations, is associated with, and thought to result from, marked ocular astigmatism. 2. For normal subjects, the general relation between spatial frequency and the evoked response is similar to psychophysical contrast sensitivity data. Evoked response amplitudes to oblique gratings are typically reduced and this is analogous to the lower acuity for oblique compared to horizontal and vertical detail. 3. In addition to the oblique effect, the magnitude of the evoked response for meridional amblyopes depends upon grating orientation over most of the spatial frequency range tested (0‐5‐16 cycles/deg). The lowest evoked amplitude is found when stimulus grating orientation matches that for which acuity is reduced. 4. The evoked potentials spatial frequency response functions are qualitatively similar to contrast sensitivity functions determined with the same abnormal subjects. 5. From these results, it may be concluded that the physiological locus of meridional amblyopia is confined primarily to structures at or prior to the site of evoked potential generation.