Sex Hormones as Protective Agents Against Radiation Mortality in Mice.

Publisher Website
Google Scholar
Abstract
50% mortality occurs by the 20th day in dba mice exposed to acute lethal doses of X-rays. Diethylstilbestrol injected subcut. 7 days before or after irradiation causes a 30% survival at 60 days. Estradiol benzoate given in the same manner causes about 80% survival at 60 days. Postirradiation admn. of estrogen has not hitherto been known to afford protection. The effect in dba mice is believed to be strain specific since they show a pronounced sensitivity to head irradiation. The results suggest that there is an interval of about 3 days immediately after irradiation in which protective action does not occur. Testosterone propionate and depo-testosterone cyclopentylpropionate did not alter mortality.

This publication has 0 references indexed in Scilit: