Increased Nerve-Growth-Factor β-Chain Cross-Reacting Material in Familial Dysautonomia
- 16 September 1976
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 295 (12) , 629-634
- https://doi.org/10.1056/nejm197609162951201
Abstract
To determine whether dysautonomia arises from alteration in nerve-growth factor (NGF), we measured serum levels of NGF subunits in normal and dysautonomic subjects using a biologic assay based on neurite outgrowth from chick ganglions, a binding assay based on displacement of Radio-labeled βNGF from rabbit-ganglion microsomes, and radioimmunoassays of α, γ and βNGF subunits via antiserum to mouse NGF polypeptides.This publication has 23 references indexed in Scilit:
- CURRENT CONCEPTS OF DYSAUTONOMIA: NEUROPATHOLOGICAL DEFECTS*Annals of the New York Academy of Sciences, 1974
- Distribution and Immunology of Mammalian Nerve Growth FactorNature, 1973
- CAVEAT TO PROTEIN REPLACEMENT THERAPY FOR GENETIC DISEASE: IMMUNOLOGICAL IMPLICATIONS OF ACCURATE MOLECULAR DIAGNOSISThe Lancet, 1973
- Adsorption of Nerve Growth Factor onto Surfaces Implications for the Assay in Tissue CultureEuropean Journal of Biochemistry, 1973
- Effects of Nerve Growth Factor antiserum on peripheral unmyelinated nerve fibersActa Neuropathologica, 1972
- A SENSITIVE RADIOIMMUNOASSAY FOR 7S NERVE GROWTH FACTOR ANTIGENS IN SERUM AND TISSUESJournal of Neurochemistry, 1971
- Sensory, motor, and autonomic dysfunctionNeurology, 1971
- FAMILIAL DYSAUTONOMIAMedicine, 1970
- Tissue culture assay of Nerve Growth Factor and of the specific antiserumExperimental Cell Research, 1970
- Albumin from heated human plasma. I. Preparation and electrophoretic propertiesArchives of Biochemistry and Biophysics, 1954