Antihypertensive action of bendroflumethiazide: Increased prostacyclin production?

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Abstract
A within‐patient randomized, double‐blind, crossover study was performed to investigate mechanisms of action of bendroflumethiazide in mild essential hypertension. Significant reductions in lying, standing, and postexercise blood pressure were seen after both 3 days and 10 wk treatment with bendroflumethiazide 10 mg daily. Plasma levels of 6‐oxo‐PGF1α, the chemical hydrolysis product of prostacyclin, were increased by both 3 days and 10 wk therapy with bendroflumethiazide. This raises the possibility that thiazides may reduce peripheral resistance by increasing prostacyclin biosynthesis. Clinical Pharmacology and Therapeutics (1980) 28, 751–758; doi:10.1038/clpt.1980.231