Decrease in Factor VII Coagulant Activity during Percutaneous Transluminal Coronary Angioplasty by Heparin-Mediated Lipolytic Action
- 1 April 1997
- journal article
- clinical trial
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 77 (04) , 675-678
- https://doi.org/10.1055/s-0038-1656032
Abstract
Summary: Levels of factor VII coagulant activity (FVII: C) and two-chain factor Vila antigen (FVIIa: Ag) were measured in ten patients before and up to 6 h after receiving a bolus of heparin during percutaneous transluminal coronary angioplasty (PTCA). A significant and sustained post-heparin fall in the level of FVII: C was observed (approximately 30%) without any change in the level of FVIIa: Ag. The level of tissue factor antigen within the circulation remained unchanged. The observed decrease in FVII: C coincided with a significant decrease in triglyceride levels presumably due to lipoprotein and hepatic lipase released by the heparin. These findings appear to demonstrate a lipid (triglyceride) dependence of FVII: C. Thus, heparin may act indirectly as antithrombotic agent by limiting a lipid-dependent activation of the extrinsic pathway of coagulation.Keywords
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