Degradation Rate in Rat Liver Homogenate in Relation to Antibacterial Activity of Various Nitrofuran Derivatives

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Abstract
Fourteen nitrofuran derivatives were comparatively examined for the ratio of their degradation rate in rat liver homogenates to their corresponding antibacterial activities. Results are shown in Table I and Fig. 1. This ratio probably indicates whether a sample should be used as a chemotherapeutic (when the ratio is more than 2) or as a preservative (when less than 1). Discussions were given about this relationship.

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