Reduced Secretion of lnterleukin-1 and Tumor Necrosis Factor-α by Neonatal Monocytes
- 1 January 1993
- journal article
- research article
- Published by S. Karger AG in Neonatology
- Vol. 63 (3) , 157-162
- https://doi.org/10.1159/000243926
Abstract
Monocytes were isolated from peripheral blood of preterm and term newborn infants and adult controls, and their capacity to secrete the inflammatory mediators interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) was investigated. Lipo-polysaccharide (LPS)-stimulated neonatal monocytes secreted significantly less IL-1 (median: 1.1 U/ml) than monocytes from adult controls (median: 7.3 U/ml). In addition TNF-α production by LPS-stimulated neonatal monocytes (median: 610 pg/ml) was significantly lower when compared with controls (median: 2230 pg/ml). Our data provide evidence that neonatal monocytes have a profoundly impaired cytokine secretion.Keywords
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