Conformational equilibria in N,3- and N,4-dimethylpiperidine
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 20,p. 844-845
- https://doi.org/10.1039/c39750000844
Abstract
The conformational equilibrium free energy difference for the C-methyl group in N,3- and N,4-dimethylpiperidine, and therefore in 3- and 4-methylpiperidine to a good approximation, have been estimated to be 6.3 ± 0.3 and 8.3 ± 0.3 kJ mol–1 at 293 K in dodecane as solvent, using the ratios of diastereomeric ions formed by the kinetically controlled protonation of 13C isotopically enriched derivatives.Keywords
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