IMAGING OF BRAIN-TUMORS WITH L-3-[I-123]IODO-ALPHA-METHYL TYROSINE AND SPECT

  • 1 January 1989
    • journal article
    • research article
    • Vol. 30  (1) , 110-112
Abstract
Carbon-11-labeled amino acids have been successfully used to image brain tumors by PET. This study was undertaken to evaluate the potential of L-3-[123I]-iodo-.alpha.-methyl tyrosine (123IMT) for metabolic imaging of brain tumors. Ten patients (glioblastoma, oligodendroglioma, lymphoma, and metastases) had early and delayed brain SPECT with a rotating gamma camera after i.v.-injection of 200-300 MBq 123IMT. In nine patients the tumor showed intense uptake of the radiotracer. Tumor-to-brain tissue ratios were between 1.4 and 2.6. 123IMT shows potentials for monitoring the effects of brain tumor therapy.

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