Isoniazid as an inhibitor of primidone metabolism
- 1 December 1975
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 25 (12) , 1179
- https://doi.org/10.1212/wnl.25.12.1179
Abstract
Isoniazid inhibited the metabolism of primidone in a patient with focal seizures. The steady-state serum level of primidone rose when the patient received both drugs simultaneously. The serum levels of the primidone metabolites, phenobarbital and phenylethyl-malonamide, fell and the rats of metabolism of primidone decreased. The results are similar to those observed when isoniazid is administered with diphenylhydantoin.Keywords
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