Synthesis of 2,4-diaza-4-deoxypodophyllotoxin, a new analogue of podophyllotoxin possessing antitumour activity
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 1,p. 49-50
- https://doi.org/10.1039/c39950000049
Abstract
2,4-Diaza-4-deoxypodophyllotoxin 4 and its cis analogue 14 are synthesised stereoselectively from 3,4-methylenedioxyaniline 5, and show significant activity against vincristine-resistant P-388 leukaemia in vivo.Keywords
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