Defining the role of endothelins in renal pathophysiology on the basis of selective and unselective endothelin receptor antagonist studies
- 1 July 1995
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Nephrology and Hypertension
- Vol. 4 (4) , 349-353
- https://doi.org/10.1097/00041552-199507000-00011
Abstract
The sensitivity of the renal vasculature to endothelin-1 together with the effect of the peptide on the kidney prompted investigators to study the role of endothelin-1 in renal pathophysiology. The kidney expresses both endothelinA and endothelinB receptors, which differ from species to species. Experiments employing specific endothelin receptor antagonists in experimental animals have suggested a role for endothelin-1 in ischaemia-induced acute renal failure and renal disease progression.Keywords
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