Direct chiral resolution of amino acid derivatives by capillary electrophoresis

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Abstract
A mixture of sodium deoxycholate and β‐cyclodextrin has been used to resolve the enantiomers of the 1‐cyano‐2‐substituted‐benz[L]isoindole and dansyl derivatives of a variety of amino acids. The enantiomers of CBI‐histidine and glutamic acid were resolved with this system unlike the case of γ‐cyclodextrin in combination with SDS reported in the literature. Dansyl derivatives have been generated in situ to provide information about the migration behavior of dansylic acid, a major by‐product in the dansylation.