A model independent method for estimating the in vivo release rate constant of a drug from its oral formulations
- 1 June 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 28 (6) , 505-507
- https://doi.org/10.1111/j.2042-7158.1976.tb02775.x
Abstract
A simple equation by which the first-order release rate constant of a drug from its oral formulation can be calculated is derived. The derivation is independent of any hypothetical concepts of drug distribution or elimination.This publication has 6 references indexed in Scilit:
- Derivation of general equations for linear mammillary models when the drug is administered by different routesJournal of Pharmacokinetics and Biopharmaceutics, 1975
- Application of the Loo-Riegelman absorption methodJournal of Pharmacokinetics and Biopharmaceutics, 1975
- Application of the Wagner-Nelson absorption method to the two-compartment open modelJournal of Pharmacokinetics and Biopharmaceutics, 1974
- An analysis of the inter-subject variation in the metabolism of pentazocineJournal of Pharmacy and Pharmacology, 1974
- A general method of determining the first order input rate constant of a drug that is directly absorbed into the central compartmentJournal of Pharmacy and Pharmacology, 1974
- New Method for Calculating the Intrinsic Absorption Rate of DrugsJournal of Pharmaceutical Sciences, 1968