Binding induced conformational changes of proteins correlate with their intrinsic fluctuations: a case study of antibodies
Open Access
- 1 January 2007
- journal article
- Published by Springer Nature in BMC Structural Biology
- Vol. 7 (1) , 31
- https://doi.org/10.1186/1472-6807-7-31
Abstract
How antibodies recognize and bind to antigens can not be totally explained by rigid shape and electrostatic complimentarity models. Alternatively, pre-existing equilibrium hypothesis states that the native state of an antibody is not defined by a single rigid conformation but instead with an ensemble of similar conformations that co-exist at equilibrium. Antigens bind to one of the preferred conformations making this conformation more abundant shifting the equilibrium.Keywords
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