Effect of Flurazepam on Sleep in the Laboratory

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Abstract
A new hypnotic drug, flurazepam, was given to six healthy young men in a blind trial involving sleep on four consecutive nights in the laboratory. Continuous recordings of the electro-encephalogram, electro-oculogram and electrical resistance of palmar skin made throughout the night enabled sleep to be analyzed objectively in terms of the usual stages. Sleep on the third night, when flurazepam 15 mg was taken, was compared with that on the second and fourth nights, when a placebo was taken. Flurazepam permitted sleep which was objectively better and subjectively as good as the best sleep without the drug. There was no inhibition either of REM-sleep or of δ-wave sleep as occurs with many other hypnotics.

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