SAFETY OF PROLONGED AORTIC CLAMPING WITH BLOOD CARDIOPLEGIA .2. GLUTAMATE ENRICHMENT IN ENERGY-DEPLETED HEARTS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 88  (3) , 402-410
Abstract
Cold blood cardioplegic techniques are limited in their ability to protect energy-depleted [canine] heart during aortic clamping. Previous observations on the benefits of amino acid (L-glutamate) enrichment of blood carioplegic solutions as well as the added metabolic benefits of normothermic induction of cardioplegic arrest to increase the rate of repair of energy-depleted hearts were extended. L-Glutamate enrichment of blood cardioplegic solutions significantly improved metabolic recovery (greater O2 consumption, better anaerobic metabolism) and ventricular performance. Normothermic induction of glutamate-enriched cardioplegia allowed complete recovery of myocardial metabolism and function compared to cold blood cardioplegic technique and may be used as a form of active resuscitation of energy depleted hearts.

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