Infection, Dermatitis, Increased IgE, and Impaired Neutrophil Chemotaxis
- 1 October 1976
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 112 (10) , 1387-1390
- https://doi.org/10.1001/archderm.1976.01630340005001
Abstract
† Eleven patients with recurrent bacterial infections were found to have impaired neutrophil chemotaxis. The infections were primarily staphylococcal abscesses involving the skin and the respiratory tract. All patients had chronic eczematous dermatitis and an elevated level of serum IgE. The peripheral blood eosinophil count was equal to or greater than 10% of the circulating leukocytes in 10 of 11 patients. Associated findings in some patients included urticaria and oral or cutaneousCandidainfection. These observations suggest a relationship between chronic dermatitis, elevated serum IgE level, eosinophilia, defective neutrophil chemotactic responsiveness, and recurrent pyogenic infections of skin and lungs. (Arch Dermatol112:1387-1390, 1976)Keywords
This publication has 3 references indexed in Scilit:
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- Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritisJournal of Clinical Investigation, 1971
- Histamine Augments Leukocyte Adenosine 3′,5′-Monophosphate and Blocks Antigenic Histamine ReleaseScience, 1971