Intact Chemoreceptor-Based Biosensors: Extreme Sensitivity to Some Excitatory Amino Acids

Abstract
An intact chemeoreceptor-based biosensor is used to detect some compounds belonging to the excitatory amino acid group. The biosensor responds to concentrations of kainic acid and quisqualic acid as low as 10−15M, representing an increase in sensitivity of approximately nine orders of magnitude over more traditional potentiometric biosensors. Moreover, the intact chemoreceptor-based biosensor responds to a new class of compounds not previously detected with a biosensor.