Toll-Like Receptor 2 Deficiency Delays Pneumococcal Phagocytosis and Impairs Oxidative Killing by Granulocytes
Open Access
- 1 December 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (12) , 8397-8401
- https://doi.org/10.1128/iai.73.12.8397-8401.2005
Abstract
Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2 −/− ) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2 −/− PMN. These cells exhibited also a lower oxidative bactericidal activity against S. pneumoniae than WT PMN, suggesting that TLR2 modulates bacterial clearance in PMN.Keywords
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