Abstract
Rates in particular for default from clinics and to a lesser degree non-compliance to treatment for patients with pulmonary tuberculosis have rarely been described quantitatively in the literature. In this report we describe studies in which an out-patient population in rural Pakistan was found retrospectively to have a default rate of 66%, and a non-compliance rate of 53% for P.A.S. and 60% for isoniazid measured by objective pharmacological tests. Suggestions are made for a change from the established out-patient approach, to intermittent high dose chemotherapy administered by health workers in the community.

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