Radioimmunoassay of Hepatitis B Core Antigen and Antibody with Autologous Reagents1
- 1 December 1977
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 33 (6) , 369-372
- https://doi.org/10.1111/j.1423-0410.1977.tb02259.x
Abstract
Anti-HBc [hepatitis B core] antigen is the most sensitive indicator of current or recent hepatitis B virus infection, hence its detection is valuable in laboratory diagnosis of the infection. Dane particles isolated from the plasma of a single chronic [human] carrier and his autologous Ig[immunoglobulin]G labeled with 125I were utilized in a solid-phase sandwich radioimmunoassay for anti-HBc. The principle of serologic neutralization of core antigen and consequent inhibition of binding of the cores to the solid-phase rendered the method to be a simple, sensitive, specific and rapid means of detecting anti-HBc.Keywords
This publication has 11 references indexed in Scilit:
- Hepatitis B Immune Globulin — Prevention of Hepatitis from Accidental Exposure among Medical PersonnelNew England Journal of Medicine, 1975
- Immunologic mechanisms in hepatitis B assayed by antigen-binding lymphocytesThe Lancet Healthy Longevity, 1975
- Antibody to hepatitis B core antigenThe Lancet Healthy Longevity, 1975
- Structural and immunoreactive characteristics of hepatitis B core antigenThe Lancet Healthy Longevity, 1975
- DNA and DNA polymerase in the core of the Dane particle of hepatitis BThe Lancet Healthy Longevity, 1975
- A Sensitive Test for Antibody Against the Hepatitis B Core Antigen (Anti-HBc)Vox Sanguinis, 1975
- Hepatitis B antigen ??? an incomplete historyThe Lancet Healthy Longevity, 1975
- Antibody to Hepatitis B Core AntigenNew England Journal of Medicine, 1974
- Radioimmunoassay for the Detection of the Core of the Dane Particle and Antibody to ItIntervirology, 1973
- Defective Viral Particles and Viral Disease ProcessesNature, 1970