Muscle pyruvate oxidation following denervation and reinnervation
- 1 October 1983
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 6 (8) , 557-560
- https://doi.org/10.1002/mus.880060804
Abstract
Muscle pyruvate metabolism was studied in rats following sciatic nerve crush. Control studies showed high pyruvate dehydrogenase and lipoamide dehydrogenase enzyme activity in muscle with type 1 fiber predominance (soleus) and low activities in muscle with type 2 fiber predominance (extensor digitorum longus), whereas lactate dehydrogenase was much higher in the latter. Following denervation, both muscles showed a significant reduction in pyruvate dehydrogenase enzyme activity. During reinnervation, muscle with type 2 predominance developed significantly elevated pyruvate oxidation enzyme activities.This publication has 20 references indexed in Scilit:
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