Bedtime insulin injections: an alternative regimen.

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Abstract
Sixteen children (aged 3-12 yr) participated in a 12 mo. crossover study comparing bedtime with teatime insulin injections in an endeavor to reduce morning hyperglycemia. Blood glucose values were lower at lunch and at teatime on the later injection, but higher at bedtime and midnight. There was no overall change in glycosylated Hb. Despite more frequent mild hypoglycemia attacks, parents preferred the convenience of the later injection. Analysis of individual children''s glycosylated Hb values showed that those whose metabolic control improved on the later injection were younger and went to bed earlier, indicating that this regimen may have a place in the management of younger children with diabetes mellitus.