Condensation of N,N-bis(trimethylsilyl)formamide with aldehydes: a general method for the synthesis of 1-formamido-1-trimethylsilyloxyalkanes
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1658-1659
- https://doi.org/10.1039/c39860001658
Abstract
Reaction of bis(trimethylsilyl)formamide with simple aldehydes gives 1-formamido-1-trimethylsilyloxyalkanes (and the corresponding adducts with ketones), which undergo displacement of trimethylsilanol by a variety of nucleophiles to give α-substituted amides.Keywords
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