Chemotactic cell sorting inDictyostelium discoideum

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Abstract
We made mixed mounds of vitally stained prestalk cells and unstained prespore cells, from Dictyostelium discoideum(Dd), and exposed these to external 3′,5′-cyclic-AMP (c-AMP) sources. We show that prestalk cells will sort out by moving directionally toward c-AMP sources held at < 10−5 M C-AMP. This is evidence for cell sorting via chemotaxis. We present arguments that the natural cell sorting, observed during Dd development, is also chemotactic to c-AMP.