Hypocalciuric Effects of Hydrochlorothiazide in the Rat during NaHCO3, NaCl and NH4C1 Loading
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in Kidney and Blood Pressure Research
- Vol. 7 (3) , 185-191
- https://doi.org/10.1159/000172937
Abstract
Hydrochlorothiazide (HCTZ) and NaHCO3 each lower urinary calcium excretion, while NaCl and NH4Cl each increase urinary calcium. This study examines the ability of HCTZ to lower urinary calcium during NaHCO3, NaCl and NH4Cl loading in the rat. We show that HCTZ lowers urinary calcium in rats treated with NaHCO3, NaCl and NH4Cl. We demonstrate that urinary calcium excretion is depressed to a greater degree by administering NaHCO3 and HCTZ in combination than by administering these agents separately.Keywords
This publication has 15 references indexed in Scilit:
- Effects of metabolic acidosis and alkalosis on sodium and calcium transport in the dog kidneyKidney International, 1979
- Effect of Hydrochlorothiazide on Calcium Excretion by the Isolated Perfused Rat KidneyExperimental Biology and Medicine, 1979
- Thiazide diuretics do not potentiate cAMP response to parathyroid hormoneMetabolism, 1978
- Renal Calcium Reabsorption Caused by Bicarbonate and by Chlorothiazide in Patients with Hormone Resistant (Pseudo) Hypoparathyroidism*Journal of Clinical Endocrinology & Metabolism, 1978
- Calcium and Sodium Excretion in Rats in Response to Prolonged Treatment with PolythiazideNephron, 1978
- Effects of Parathyroid Hormone on Sodium and Calcium Transport in the Dog NephronClinical Science, 1976
- Studies of the Mechanism by Which Chronic Metabolic Acidosis Augments Urinary Calcium Excretion in Man*Journal of Clinical Investigation, 1967
- The Net Balance of Acid in Subjects Given Large Loads of Acid or Alkali*Journal of Clinical Investigation, 1965
- Effect of Variations in Sodium Intake on Calcium Excretion in Normal Humans.Experimental Biology and Medicine, 1964
- METABOLIC STUDIES IN PATIENTS WITH HYPERCALCIURIA1964